2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W013186S1
    Lansoprazole sulfide-13C6
    Lansoprazole sulfide-13C6 is a deuterated labeled Lansoprazole sulfide.
    Lansoprazole sulfide-<sup>13</sup>C<sub>6</sub>
  • HY-122813
    Dabigatran acyl-β-D-glucuronide
    Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
    Dabigatran acyl-β-D-glucuronide
  • HY-113322
    3-Hydroxyquinine
    3-Hydroxyquinine is a metabolite of Quinidine (HY-B1751). 3-Hydroxyquinine prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in an isolated rat heart reperfusion arrhythmia model in a concentration-dependent manner. 3-Hydroxyquinine can be used in the study of cardiac arrhythmias.
    3-Hydroxyquinine
  • HY-G0017R
    N-Desmethyl imatinib (Standard)
    Clobutinol (hydrochloride) (Standard) is the analytical standard of Clobutinol (hydrochloride). This product is intended for research and analytical applications. Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research.
    N-Desmethyl imatinib (Standard)
  • HY-W338852R
    Gentisuric acid (Standard)
    Gentisuric acid (Standard) is the analytical standard of Gentisuric acid. This product is intended for research and analytical applications. Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)[1][2].
    Gentisuric acid (Standard)
  • HY-23093R
    L-Aspartyl-L-phenylalanine (Standard)
    L-Aspartyl-L-phenylalanine (Standard) is the analytical standard of L-Aspartyl-L-phenylalanine. This product is intended for research and analytical applications. L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a Ki of 11 μM.
    L-Aspartyl-L-phenylalanine (Standard)
  • HY-135375
    O-Methyl Atorvastatin calcium
    O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    O-Methyl Atorvastatin calcium
  • HY-116016AR
    Etilevodopa hydrochloride (Standard)
    Etilevodopa (hydrochloride) (Standard) is the analytical standard of Etilevodopa (hydrochloride). This product is intended for research and analytical applications. Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].
    Etilevodopa hydrochloride (Standard)
  • HY-W699866
    Gemfibrozil 1-O-β-glucuronide-d6
    Gemfibrozil 1-O-β-glucuronide-d6 is the deuterium labeled Gemfibrozil 1-O-β-glucuronide (HY-129993). Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.
    Gemfibrozil 1-O-β-glucuronide-d<sub>6</sub>
  • HY-W144308R
    Tetrachlorohydroquinone (Standard)
    Tetrachlorohydroquinone (Standard) is the analytical standard of Tetrachlorohydroquinone (HY-W144308). This product is intended for research and analytical applications. Tetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents.
    Tetrachlorohydroquinone (Standard)
  • HY-131275
    Imatinib Impurity E
    Imatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.
    Imatinib Impurity E
  • HY-G0007S
    Omeprazole sulfone-d3
    Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
    Omeprazole sulfone-d<sub>3</sub>
  • HY-131579R
    Deschloro Cetirizine dihydrochloride (Standard)
    Pyrocatechuic acid (Standard) is the analytical standard of Pyrocatechuic acid. This product is intended for research and analytical applications. Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
    Deschloro Cetirizine dihydrochloride (Standard)
  • HY-G0023R
    Niraparib metabolite M1 (Standard)
    Berberine (hemisulfate) (Standard) is the analytical standard of Berberine (hemisulfate). This product is intended for research and analytical applications. Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity.
    Niraparib metabolite M1 (Standard)
  • HY-100655R
    O-Desmethyl apixaban (Standard)
    O-Desmethyl apixaban (Standard) is the analytical standard of O-Desmethyl apixaban. This product is intended for research and analytical applications. O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
    O-Desmethyl apixaban (Standard)
  • HY-G0021R
    N-Desmethylclozapine (Standard)
    N-Desmethylclozapine (Standard) is the analytical standard of N-Desmethylclozapine. This product is intended for research and analytical applications. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
    N-Desmethylclozapine (Standard)
  • HY-148846
    Mosapride N-Oxide
    Mosapride N-Oxide is a major active metabolite of Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
    Mosapride N-Oxide
  • HY-133797
    Cyclobenzaprine N-oxide
    Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine.
    Cyclobenzaprine N-oxide
  • HY-W021399S
    Lidocaine impurity 5-d6
    Lidocaine impurity 5-d6 is deuterium labeled Lidocaine impurity 5.
    Lidocaine impurity 5-d<sub>6</sub>
  • HY-N16390A
    (9Z)-16-Hydroxy-9-hexadecenoic acid
    (9Z)-16-Hydroxy-9-hexadecenoic acid is an unsaturated hydroxy fatty acid. (9Z)-16-Hydroxy-9-hexadecenoic acid can be produced by the fermentation of Methyl palmitoleate (HY-W011688) using the yeast Torulopsis apicola.
    (9Z)-16-Hydroxy-9-hexadecenoic acid
Cat. No. Product Name / Synonyms Application Reactivity