2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12798E
    (R)-AR-13503
    		98.20%
    (R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research.
    (R)-AR-13503
  • HY-143974S
    Imiquimod impurity 1-d6
    Imiquimod impurity 1-d6 is the deuterium labeled Imiquimod impurity 1.
    Imiquimod impurity 1-d<sub>6</sub>
  • HY-101108R
    Tazarotenic acid (Standard)
    Deoxycholic acid (Standard) is the analytical standard of Deoxycholic acid. This product is intended for research and analytical applications. Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
    Tazarotenic acid (Standard)
  • HY-135373
    Desfluoro-atorvastatin
    Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    Desfluoro-atorvastatin
  • HY-111742
    Bifenazate-diazene
    Bifenazate-diazene is a major degradation product of Bifenazate. Bifenazate is a selective carbazate acaricide and an insecticide.
    Bifenazate-diazene
  • HY-118247
    Ro 14-6113
    Ro 14-6113 is an inactive phenolic metabolite of the "carotenoid" Ro 15-0778, a form of vitamin A.
    Ro 14-6113
  • HY-78846
    2R,4R-Sacubitril
    		98.66%
    2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2R,4R-Sacubitril
  • HY-W751669
    9-Fluorenol-d9
    9-Fluorenol-d9 (9-Hydroxyfluorene-d9) is the deuterium labeled 9-Fluorenol (HY-W016388). 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol-d<sub>9</sub>
  • HY-W742805
    Sulindac Sulfone-d6
    Sulindac Sulfone-d6 is the deuterium labeled Sulindac sulfone (HY-B1787). Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research.
    Sulindac Sulfone-</sub>d<sub>6</sub>
  • HY-129491S
    O-Desmethyl Midostaurin-d5
    O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism.
    O-Desmethyl Midostaurin-d<sub>5</sub>
  • HY-169046
    (±)13,14-DiHDoTrE
    (±)13,14-DiHDoTrE ((±)13,14-DHDT) is an oxylipin and a metabolite of Adrenic acid (HY-W013215).
    (±)13,14-DiHDoTrE
  • HY-138166R
    Rosuvastatin lactone (Standard)
    Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone (Standard)
  • HY-147323R
    Ferulic acid 4-O-sulfate (Standard)
    Ferulic acid 4-O-sulfate (Standard) is the analytical standard of Ferulic acid 4-O-sulfate. This product is intended for research and analytical applications. Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid (HY-N0060). Ferulic acid 4-O-sulfate relaxes arteries and lowers blood pressure in mice[1].
    Ferulic acid 4-O-sulfate (Standard)
  • HY-G0016
    N-Acetyl dapsone
    N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities.
    N-Acetyl dapsone
  • HY-15793A
    Trans (2,3)-Dihydrotetrabenazine
    Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).
    Trans (2,3)-Dihydrotetrabenazine
  • HY-114461B
    (3S,17S)-FD-895
    (3S,17S)-FD-895 is a FD-895 analogue. (3S,17S)-FD-895 can inhibit the growth of HCT116 cells and has splicing regulation activity. (3S,17S)-FD-895 can be used in the study of cancer.
    (3S,17S)-FD-895
  • HY-144203S
    Trospium EP impurity C-d8 chloride
    Trospium EP impurity C-d8 (chloride) is the deuterium labeled Trospium EP impurity C chloride.
    Trospium EP impurity C-d<sub>8</sub> chloride
  • HY-133787R
    Levofloxacin N-oxide (Standard)
    Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
    Levofloxacin N-oxide (Standard)
  • HY-W585893
    Endrin ketone
    Endrin ketone is an Endrin (HY-W585893) degradation product. Endrin is a carcinogen.
    Endrin ketone
  • HY-N15575
    Rhamnitol
    Rhamnitol is the reduction product of L-rhamnose that can be found in the metabolism of ingested rhamnose in the body. Rhamnitol is promising for research of intestinal permeability assessment and carbohydrate metabolism.
    Rhamnitol
Cat. No. Product Name / Synonyms Application Reactivity